Cooperative interactions of BRAF kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
نویسندگان
چکیده
Departments of Pediatrics, Neurological Surgery, Neurology, and Neuropathology, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, and Department of Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143; and Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057
منابع مشابه
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with homozygous cyclin-dependent kinase inhibitor 2A (CDKN2A, encoding p14ARF and p16Ink4a) deletions in pedi...
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تاریخ انتشار 2012